‘Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth’ by authors Giovanni Germano, Simona Lamba, Giuseppe Rospo, Ludovic Barault, Alessandro Magrì, Federica Maione, Mariangela Russo, Giovanni Crisafulli, Alice Bartolini, Giulia Lerda, Giulia Siravegna, Benedetta Mussolin, Roberta Frapolli, Monica Montone, Federica Morano, Filippo de Braud, Nabil Amirouchene-Angelozzi, Silvia Marsoni, Maurizio D’Incalci, Armando Orlandi, Enrico Giraudo, Andrea Sartore-Bianchi, Salvatore Siena, Filippo Pietrantonio, Federica Di Nicolantonio & Alberto Bardelli was published in Nature and online 29 November 2017. Abstract: Molecular alterations […]
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Entries by mercuric
Ruth Boyd and Margaret Grayson will present MErCuRIC as a case study in Patient and Public Involvement (PPI) in research at the European Alliance for Personalised Medicine Conference which is being held this week in Belfast, UK. The conference theme is ‘Personalising Your Health: A Global Imperative!’ and runs from 27- 30 November 2017. Patient […]
Our MErCuRIC partners at the University of Torino (UNITO) have recently published two important papers. One appears in the October 5, 2017, edition of Gut, “Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer.” The second paper titled, “Tracking a CAD-ALK gene rearrangement in urine and blood […]
The 1st European Alliance for Personalised Medicine Congress – ‘Forward As One: Making personalised medicine a reality at national level’ is being held 27 – 30 Nov 2017 in Belfast, Northern Ireland. The congress will be interactive, focusing on diseases, general science issues (Big Data, genomics, clinical trials, etc.) and the views, progress and health landscapes across Europe. With […]
ESMO Workshop: Science for Advocates Munich – 13 – 15 October 2017 Click here to apply and for further details. Travel grants available in limited number. ‘Science for advocates’ will be a 2-day interactive workshop (Friday afternoon till Sunday lunch-time) with a combination of lectures, independent and group work. To ensure effective communication, the workshop […]
EUPATI as an EPF programme is approaching the end of its first year, and EPF President Marco Greco evaluates the achievements – and challenges – of this new environment and shares his perspectives here. The EUPATI Training Course Patient Experts in Medicines Research & Development has 57 new participants in cohort three. This exciting and unique […]
Join EUPATI‘s webinar to hear about patients relating their experience when going through Health Technology Assessment (HTA) processes. Two EUPATI Fellows, Paola Kruger (Italy) and Joan Jordan (Ireland) will share their experiences. The point of view of the pharmaceutical industry involved in the HTA process will also be highlighted. Two representatives from Roche, David McCarthy and […]
Hajrah A. Khawaja, a post-graduate student in the School of Medicine, Dentistry and Biomedical Sciences, Centre for Cancer Research and Cell Biology, at Queen’s University of Belfast, UK presents her poster ‘RalB GTPase: A potential novel target for RAS mutant colorectal cancer‘ at the European Society for Medical Oncology conference. ESMO 2017 will be held […]
The UNITO team (D. Oddo et al.) has just published Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer in the British Journal of Cancer (DOI: 10.1038/bjc.2017.196). Background: Combined MET and BRAF inhibition showed clinical benefit in a patient with rectal cancer carrying BRAFV600E and MET amplification. However, after 4 months, acquired […]
MErCuRIC researchers have recently published a review in Nature Reviews Clinical Oncology. Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges Conor A. Bradley, Manuel Salto-Tellez, Pierre Laurent-Puig, Alberto Bardelli, Christian Rolfo, Josep Tabernero, Hajrah A. Khawaja, Mark Lawler, Patrick G. Johnston, Sandra Van Schaeybroeck & on behalf of the MErCuRIC consortium Data from many preclinical studies, including those using cellular models of colorectal, gastric, gastro-oesophageal and […]
MErCuRIC is funded by the European Community’s Framework Programme Seven (FP7) under contract #602901. The material presented and views expressed here are the responsibility of the author(s) only. The EU Commission takes no responsibility for any use made of the information set out.